Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in caucasians with hypertension

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Abstract

Background/Aims: Hyperuricemia is associated with obesity and the metabolic syndrome. URAT1 is a urate transporter, and we tested the association of URAT1 transporter gene (SLC22A12) polymorphisms with obesity and the metabolic syndrome in hypertensive subjects. Methods: Patients with essential hypertension (n = 414) from a randomized controlled study were genotyped for SLC22A12 SNPs rs11602903, rs505802 and rs11231825. Results: In Caucasians, SLC22A12 SNPs were associated with the body mass index (BMI). rs11602903 was associated with BMI (p < 0.0001), waist circumference (p = 0.003), HDL cholesterol (p = 0.018) and the metabolic syndrome (p = 0.033), and accounted for 7% of the variation of BMI in Caucasians. In African Americans, SLC22A12 SNP rs11602903 was not associated with BMI, waist circumference, HDL cholesterol or triglycerides. Conclusion: The URAT1 gene SLC22A12 polymorphism may play a role in obesity and the metabolic syndrome in Caucasian hypertensive subjects. Copyright © 2012 S. Karger AG, Basel.

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Shafiu, M., Johnson, R. J., Turner, S. T., Langaee, T., Gong, Y., Chapman, A. B., … Johnson, J. A. (2013). Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in caucasians with hypertension. Kidney and Blood Pressure Research, 35(6), 477–482. https://doi.org/10.1159/000337370

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