Recognizing methylated histone variant H3.3 to prevent tumors

Abstract

Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription regulation in suppressing tumors. © 2014 IBCB, SIBS, CAS All rights reserved.