Selenium nanoparticles coated with resveratrol ameliorates the neurobiochemical abnormalities by attenuating oxidative stress and improving neurotransmissions in AlCl3-Induced Alzheimer’s model of rats.

Abstract

Selenium nanoparticles coated with resveratrol ameliorates the neurobiochemical abnormalities by attenuating oxidative stress and improving neurotransmissions in AlCl3-induced Alzh... Article · January 2021 CITATIONS 0 READS 12 4 authors, including: Some of the authors of this publication are also working on these related projects: diabetes differentiation mesenchymal stem cells stem cell therapy View project parallel Numerical View project Omayma Abozaid Benha University. faculty of vet.med. ABSTRACT Keywords The present study aimed to investigate whether long-term administration of resveratrol coated with Selenium nanoparticles (RSV-Nano selenium) could shield rats from aluminum-induced AD pathogenesis and oxidative injury. Thirty male albino wistar rats were orally administered with aluminum chloride (300 mg/kg b. wt.) once daily for 30 days for induction of AD. The rats of induced model of AD were orally administrated with RSV-Nano selenium (200 mg/kg, b. wt.) once daily for 3 weeks. The rats were scarified on the 52nd and brain tissue of each rat was dissected and frozen at −80 °C. Biochemical research was conducted to determine the degree of oxidative injury through measuring Catalase, Glutathione (GSH), Malondialdehyde (MDA), γ-Secretase and Calcium levels in brain tissue. Aluminum chloride administration caused neurotoxicity and severe memory loss, as well as significant oxidative harm. It also resulted in substantial rise in γ-secretase and a significant decrease in calcium levels. RSV-Nano selenium administration increased neuronal transmission by reducing oxidative stress and metal chelation in AD model of rats (P< 0.05). In conclusion, RSV-Nano selenium protects against AD and oxidative harm caused by aluminum. AD Nano-selenium Neurotoxicity Neurotransmission Resveratrol