Microwave-assisted formation of peptide-vitamin conjugates

Abstract

Amino acid and peptide conjugates with vitamin B 3, H, E and D 3 were synthesized by using microwave irradiation in good to satisfactory yields. In addition, a novel benzotriazole-activated biotin intermediate has been introduced, which could serve as an alternative biotinylation agent. Amino acid and peptide bioconjugates of niacin I, biotin II, α-tocopherol III and cholecalciferol IV are prepared in good to satisfactory yields by using microwave assistance. In addition, a new benzotriazole-activated biotin intermediate is synthesized, which may serve as an advantageous alternative biotinylation reagent. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.