WNT5B drives osteosarcoma stemness, chemoresistance and metastasis

Abstract

Graphical Abstract • WNT5B expression is high in osteosarcoma stem cells leading to increased stem cell proliferation and migration through SOX2. • WNT5B expression in stem cells increases rates of osteosarcoma metastasis to the lungs and liver in vivo. • The hyaluronic acid degradation enzyme HYAL1 is regulated by WNT5B in osteosarcoma contributing to metastasis. • Inhibition of WNT5B with a ROR1 antibody decreases osteosarcoma stemness.