Assessment of radio-protective properties of some anti-inflammatory drugs

Abstract

When ionizing radiations are exposed to humans, numerous deleterious health effects including cancer may occur. Recently, radioprotective agents with a novel mode of action have drawn strong interest. Radioprotective agents are able to palliate, to prevent, or to handle radio-induced side-effects. In this study, in the parliamentary procedure to investigate the radioprotective effects of some pharmacological compounds, we have estimated the effective atomic number (Zeff) and electron density (Ne) of six analgesic and anti-inflammatory drugs for total photon interaction in the energy range of 1 keV–100 MeV using WinXCom. In addition, and by Geometric-Progression (G-P) method, the energy absorption (EABF) and exposure buildup factors (EBF) for incident photon energy 0.015 MeV to 15 MeV up to penetration depths of 40 mean free paths (mfp) were estimated. It has been observed that EABF and EBF posses maximum values in the intermediate energy region, where Compton scattering is the dominant photon interaction process. Among the selected compounds, Etodolac (ET) has the largest EABF and EBF, while the minimal values of EABF and EBF were recorded for Meloxicam (ME). The present work could be useful to develop novel pharmacological compounds used in radioprotection, medical diagnostics, and radiation therapy.