Abstract
Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol. Demannosyl and/or dearabinitoyl roselipins were prepared chemically or enzymatically. Demannosyl roselipins conserved the DGAT inhibitory activity, but the others lost the activity, indicating that the arabinitoyl fatty acid core is essential for eliciting the activity.
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CITATION STYLE
Tomoda, H., Tabata, N., Ohyama, Y., & Omura, S. (2003). Core structure in roselipins essential for eliciting inhibitory activity against diacylglycerol acyltransferase. Journal of Antibiotics, 56(1), 24–29. https://doi.org/10.7164/antibiotics.56.24
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