The Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) Family*

Abstract

I. IntroductionII. The Modular Structure of the Connective Tissue Growth Factor/Cysteine-Rich 61/Nephroblastoma Overexpressed (CCN) Family MembersIII. Connective Tissue Growth Factor (CTGF) A. Discovery B. Structure of the CTGF gene and protein C. CTGF mRNA production D. CTGF production, secretion, and processing E. CTGF-heparin interactions F. Biological properties of CTGF G. Mechanism of action of CTGF IV. Cyr61 A. Discovery of cyr61 B. Structure of the cyr61 gene and protein C. Cyr61 mRNA production D. Cyr61 production and secretion E. Biological properties of cyr61 F. Mechanism of action of cyr61 V. Nov A. Discovery and structure of nov B. Nov mRNA production C. Biological properties of nov VI. Elm1/WISP-1VII. Heparin-Induced CCN-Like Protein (HICP)/rCop-1/CTGF-3/WISP-2VIII. WISP-3IX. Other CCN-Like MoleculesX. Regulation of Cellular Functions by the CCN Family A. Cell cycle control B. Cell adhesion and migration C. Extracellular matrix (ECM) production XI. Biological Processes Involving the CCN Famil...