Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3- a ]quinoxaline Derivatives as Novel Anticonvulsant Agents

Abstract

2-([1,2,4]Triazolo[4,3- a ]quinoxalin-4-ylthio)acetic acid hydrazide ( 10 ) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, 1 H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them ( 14 , and 15b ) showed the best anticonvulsant activities.