Evaluation of Whole Saliva Antioxidant Capacity in Patients with Periodontal Diseases

Abstract

Background and purpose: Periodontitis is the inflammation of the supporting tissues of teeth. In this disease, overproduction of free radicals by polymorphonuclears (PMNs) will result in the imbalance between saliva's oxidants and antioxidants. Therefore, due to insufficient levels of anti-oxidants, free radicals can start chain reactions that eventually will lead to destruction of peri-odontal tissues. The purpose of this research is to compare the amount of whole saliva's antioxi-dant capacity in people with major periodontitis with that of healthy people. Methods and materials: In this case-control study, the amount of antioxidants capacity and saliva antioxidants were measured in 43 cases with periodontitis, as well as in 43 healthy people (controls); and the measurements were compared between the two groups. The amount of antioxidants capacity and their saliva antioxidants capacity was measured by FRAP (ferric reducing ability of plasma) and with the help of a Spectrophotometer. Findings: Average and Standard deviation of saliva's antioxidants was 184.25 ± 63.209 in subject group and 399.419 ± 90.298 micro moles in control group. Using the T-TEST revealed that the difference in capacity of whole saliva's antioxidants in two groups is significant. Conclusion: whole saliva's antioxidants capacity is less among patients with periodon-titis compared to control group.