A new clerodane-type diterpene, named dinor casearin X, and four known casearins (A, B, G and J) were isolated from leaves of Casearia sylvestris (Salicaceae). These compounds were evaluated for cytotoxic activity against five human cancer cell lines (A2058, HL-60, HCT, MCF-7 and HeLa) as well as against a murine melanoma cell line (B16F10-Nex2). Among these compounds, dinor casearin X exhibited the highest cytotoxic activity against HL-60 cells with IC50 of 0.51 0.11 g mL-1, whereas casearin A exhibited the highest cytotoxic activity against HCT cells (IC50 1.84 0.14 g mL-1). 2015 Sociedade Brasileira de Quimica.
CITATION STYLE
Bou, D. D., Dos Santos, A. L., Figueiredo, C. R., Farias, C. F., Matsuo, A. L., Kitamura, R. O. S., … Sartorelli, P. (2015). Dinor Casearin X, a New Cytotoxic Clerodane Diterpene from Casearia sylvestris. Journal of the Brazilian Chemical Society, 26(8), 1725–1729. https://doi.org/10.5935/0103-5053.20150128
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