Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets

Abstract

Background: Pyk2 is abundantly expressed in platelets. Results: Pyk2 regulates thromboxane A2 generation induced by both 2-methylthio-ADP and AYPGKF. Conclusion: Pyk2 is an important functional tyrosine kinase that is activated by both G12/13 and integrin αIIbβ3 in platelets. Significance: Understanding the mechanism of activation of Pyk2 enhances our understanding of the platelet inside-out and outside-in signaling events. © 2013 by The American Society.