Can aripiprazole cause parkinsonism? two cases with aripiprazole-induced parkinsonism

Abstract

The association between aripiprazole and Parkinsonism has not been well demonstrated. Our patients' present complaints started several weeks after the initiation of aripiprazole only. We present two female cases who developed extrapyramidal syndrome (EPS) after administration of aripiprazole. Neither of them had ever used any antipsychotic agent except aripiprazole and the EPS disappeared within less than a week after administration of an anticholinergic drug. The severe Parkinsonism in our cases is associated with aripiprazole. Our report emphasizes the need for careful monitoring for the development of Parkinsonian features in patients treated with aripiprazole.