The effects of exposure to titanium dioxide nanoparticles during lactation period on learning and memory of rat offspring

Abstract

Nanoscale titanium dioxide (TiO2), which is massively produced and widely used in living environment, seems to have a potential risk on human health. The central nervous system (CNS) is the potential susceptible target of nanoparticles, but the studies on this aspect are limited so far. The aim of this study was to evaluate the effects of exposure to TiO2nanoparticles during lactation period on learning and memory of offspring. Lactating Wistar rats were exposed to TiO2nanoparticles (100 mg/kg; gavage) for 21 days. The Morris water maze and passive avoidance tests showed that the exposure to TiO2nanoparticles could significantly impair the memory and learning in the offspring. Therefore, the application of TiO2nanoparticles and the effects of their exposure, especially during developmental period on human brain should be cautious. © 2013, SAGE Publications. All rights reserved.