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Incorporation of 3'-S-phosphorothiolates into RNA: potential applications in RNAi

Nucleic acids symposium series (2004) (2008) (52) 319-320
DOI: 10.1093/nass/nrn161
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Abstract

Using solid-phase synthesis, oligoribonucleotides containing multiple 3'-S-phosphorothiolate modifications have been successfully synthesized, purified and characterized, utilizing a 2'-deoxyuridine phosphorothioamidite monomer.

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Gaynor, J., Fisher, J., Campbell, B., & Cosstick, R. (2008). Incorporation of 3’-S-phosphorothiolates into RNA: potential applications in RNAi. Nucleic Acids Symposium Series (2004), (52), 319–320. https://doi.org/10.1093/nass/nrn161

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