Release profile of gentamicin sulfate from polylactide-co-polycaprolactone electrospun nanofiber matrices

Abstract

The advent and growth of resistance phenomena to antibiotics has reached critical levels,invalidating the action of a majority of antibiotic drugs currently used in the clinical field. Severalinnovative techniques, such as the nanotechnology, can be applied for creating innovative drugdelivery systems designed to modify drug release itself and/or drug administration route; moreover,they have proved suitable for overcoming the phenomenon of antibiotic resistance. Electrospunnanofibers, due to their useful structural properties, are showing promising results as antibiotic releasedevices for preventing bacteria biofilm formation after surgical operation and for limiting resistancephenomena. In this work gentamicin sulfate (GS) was loaded into polylactide-co-polycaprolactone(PLA-PCL) electrospun nanofibers; quantification and in vitro drug release profiles in static anddynamic conditions were investigated; GS kinetic release from nanofibers was studied usingmathematical models. A preliminary microbiological test was carried out towards Staphylococcusaureus and Escherichia coli bacteria.