A new sarasinoside congener, sarasinoside M2, from a marine sponge collected in the Solomon Islands

Abstract

A new sarasinoside congener (sarasinoside M2) and known sarasinoside B1 were obtained from a marine sponge. Sarasinoside M2 was suggested to have the same aglycon as sarasinoside M although the internal glucose in its sugar moiety is replaced by xylose. Sarasinosides B1 and M2 showed moderate cytotoxicity (approximate IC50 5-18 μM) toward Neuro-2a and HepG2 cell lines.