Considerations in choosing a deaeration technique for dissolution media

Abstract

Selection of a technique for deaeration of dissolution media will involve evaluation of several parameters, including effectiveness, cost and ease of use. When deciding to purchase a particular piece of laboratory equipment for dissolution deaeration, one needs a means to judge the effectiveness of the equipment. In this Case, it was necessary to demonstrate the effectiveness of deaeration (1,2). The USP method was used as a benchmark and other deaeration techniques were compared to this method. Various deaeration techniques (involving different degrees of complexity and expense) were found to be comparable to the USP method of deaeration (3,4). After determining deaeration effectiveness, one Can then choose a method based on individual laboratory needs, e.g., budget, manpower.