Preparation of pyrazole derivatives as p38 MAP kinase inhibitors and cytokine production inhibitors.

Abstract

The title compds. I [R1 is optionally substituted phenyl; R2 is H, halogeno, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, or substituted amino; Q is CH or N; R3 is H, alkyl, or amino; and R4 is a group represented by the general formula Q1, etc.; R7 is H or alkyl; R8 is H, alkyl, or substituted amino; R9 is H or alkyl] are prepd. Compds. of this invention in vitro showed IC50 values of 0.2 nM to 8.8 nM against p38 MAP kinase. Formulations are given. [on SciFinder(R)]