ESPGHAN 56th Annual Meeting Abstracts

Abstract

[...]understanding the molecular mechanism(s) activated in IEC exposed to PT represents a unique opportunity to define new potential therapeutic targets. [...]increased expression of ER stress markers was confirmed in biopsies from CD patients compared to non-CD patients. TEDDY STUDY Elin Hård Af Segerstad1, Lazarus Mramba2, Carin Andrén Aronsson3, Xiang Liu2, Ulla Uusitalo2, Jill Norris4, Suvi Virtanen5, Sibylle Koletzko6, Marian Rewers7, Jorma Toppari8, Richard Mcindoe9, Anette-G Ziegler10, William Hagopian11, Beena Akolkar12, Jeffrey Krischer2, Daniel Agardh3 1Pediatric Research Institute, Oslo University Hospital, Oslo, Norway, 2Health Informatics Institute, University of South Florida, Tampa, FL, United States of America, 3Unit Of Celiac Disease And Diabetes, Clinical Sciences Malmö, Lund University, Malmo, Sweden, 4Department Of Epidemiology, Colorado School of Public Health, Denver, United States of America, 5Finnish Institute for Health and Welfare and Tampere University and Tampere University Hospital, Tampere, Finland, 6Department Of Pediatrics, Dr. von Hauner Children's Hospital, LMU Munich, Munich, Germany, Munich, Germany, 7University of Colorado, Aurora, CO, United States of America, 8University of Turku and Turku University Hospital, Turku, Finland, 9Augusta University, Augusta, GA, United States of America, 10Technische Universität München, and Forschergruppe Diabetes e.V, Neuherberg, Germany, 11Pacific Northwest Research Institute, Seattle, United States of America, 12National Institute of Diabetes & Digestive & Kidney Diseases, Bethesda, MD, United States of America Objectives and Study: High intake of dietary fiber in pregnant women has been associated with reduced risk of coeliac disease in the offspring. Fiber intake in the first 2 years of life was associated with a reduced risk of CDA (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.92, 0.96, p<0.001) and coeliac disease (HR 0.95, 95% CI 0.91, 0.99, p=0.008, Figure).