Phytoglycoproteins and human health: Current knowledge and future applications

Abstract

Over the years, humans have relied on plants as sources of nutrients and bioactive compounds that promote health and wellness. Interestingly, drug discovery has benefitted immensely from the use of bioactive phytochemicals derived from food and medicinal plants. Phytoglyco-proteins (PGPs) are plant-derived proteins with sugar moieties covalently linked to amino acid side chains, formed by glycosylation during posttranslational modification of polypeptides. Sev-eral studies in the last two decades, including cell culture and animal studies, have documented a variety of health-beneficial effects of PGPs, including hypolipidemic, wound healing, antioxidant, anti-inflammatory, immunomodulatory, and anticancer properties. Despite the prospects, there is a dearth of information on the pharmacokinetics and toxicity of PGPs, including possible induction of immune reactions, and the potential effects of stereospecific variation in PGPs isomers on their physiological functions. Further exploration of the multifunctional glycoproteins will position them as strong candidates for the development of nutraceuticals and functional foods.