Agranulocytosis associated with lamotrigine in a patient with low-grade glioma

Abstract

Purpose: To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor. Methods: A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously. Results: After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved. Conclusions: In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.