Abstract
Stereochemical investigations have shown that the conversion of 2-hydroxyethylphosphonate to hydroxymethylphosphonate by the enzyme HEPD involves removal of the pro-S hydrogen at C2 and, surprisingly, the loss of stereochemical information at C1. As a result, the mechanisms previously proposed for HEPD must be re-evaluated. © 2011 American Chemical Society.
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CITATION STYLE
APA
Whitteck, J. T., Malova, P., Peck, S. C., Cicchillo, R. M., Hammerschmidt, F., & Van Der Donk, W. A. (2011). On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase. Journal of the American Chemical Society, 133(12), 4236–4239. https://doi.org/10.1021/ja1113326
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