Anxiolytic and antiseizure effects of Sida tiagii Bhandri

Abstract

The central nervous system (CNS) pharmacological effects of ethylacetate extract (EAS) of Sida tiagii Bhandri collected from northern province (Rajasthan) of India were assessed by elevated plus-maze, pentobarbitone induced sleeping time, spontaneous motor activity, pentylenetetrazole-induced seizure, forced swim test and rotarod tests. The results of the present study demonstrated the CNS depressant potential, i.e., anxiolytic, antiseizure, reduction in spontaneous locomotion and potentiation of pentobarbital-induced hypnosis of the plant under investigation.