Antibiotic susceptibility of Pseudomonas aeruginosa isolated from different clinical sources

Abstract

Pseudomonas aeruginosa (P. aeruginosa) is a Gram negative opportunistic pathogen which is responsible for many infections in humans. It is the causative agent of nosocomial pneumonia, urinary tract infection, surgical site infections and burn infection. Bacterial resistance to antibiotic is an increasing problems worldwide. Emergence of bacterial resistance to antimicrobials pose a challenge in treating pyogenic infection hence periodical monitoring of bacterial profile and their antibiotic susceptibility pattern is important. In current study, P. aeruginosa isolates obtained from different clinical sources were identified according to traditional biochemical tests. Antibiotic susceptibility testing was performed by the disc diffusion method. Importantly, present results show that 53% out of P. aeruginosa isolates exhibited multi drug resistance (MDR) pattern. P. aeruginosa isolates showed higher resistance to ciprofloxacin, gatifloxacin and meropenem and intermediate resistance to cefoperazone, cefepime, pipracillin, tobramycin, pipracillin-tazobactam, ceftazidime and azetreonem while Low bacterial resistance was noted against colistin only. The inappropriate use of antibiotics has led to the development of resistant bacteria which led to ineffective antibiotic therapy. Current study suggests applying of strict policies for antibiotic prescription and dispensing.