Neuroprotective effects of lacosamide in experimental traumatic spinal cord injury in rats

12Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

Abstract

AIM: To evaluate the effects of lacosamide on traumatic spinal cord injury (SCI) in rats. MATERIAL and METHODS: A total of 28 male Wistar albino rats, each weighing 300-350 g, were included. They were randomly assigned to four groups. In Group 1, only a laminectomy was performed; in Group 2, SCI was performed after laminectomy; in Group 3, SCI was performed after laminectomy followed by lacosamide administration, and in Group 4, SCI was performed after laminectomy followed by physiological saline administration. After 48 hours, all animals were sacrificed, blood samples were drawn, and their spinal cords were removed. The serum levels of catalase, glutathione peroxidase (GPx), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured, and the spinal cord specimens were examined for neuronal degeneration (PND). RESULTS: The MDA level was the lowest and the antioxidant enzyme levels were the highest in Group 3. There were statistically significant differences between Group 3 and the others in their PND score, serum MDA, SOD, GPX and catalase levels (p < 0.05). CONCLUSION: Lacosamide has a neuroprotective effect in SCI in rats that is related to its ability to decrease the production of reactive oxygen species by increasing antioxidant enzyme expression, inhibit lipid peroxidation and attenuate glial cell activation.

References Powered by Scopus

Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms

1325Citations
N/AReaders
Get full text

Current status of acute spinal cord injury pathophysiology and emerging therapies: Promise on the horizon

645Citations
N/AReaders
Get full text

Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue - a review

578Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Anticonvulsant effects of topiramate and lacosamide on pilocarpine-induced status epilepticus in rats: A role of reactive oxygen species and inflammation

21Citations
N/AReaders
Get full text

Promising Role of Nano-Encapsulated Drugs for Spinal Cord Injury

20Citations
N/AReaders
Get full text

Time course evaluation of lacosamide alone and in polypharmacy on behavioral manifestations and oxidative stress in lithium-pilocarpine-induced model

20Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Demiroz, S., Ur, K., Ulucan, A., Bengu, A. S., Demiralin Ur, F., Gergin, O. O., & Erdem, S. (2019). Neuroprotective effects of lacosamide in experimental traumatic spinal cord injury in rats. Turkish Neurosurgery, 29(5), 718–723. https://doi.org/10.5137/1019-5149.JTN.25891-19.2

Readers' Seniority

Tooltip

Researcher 5

56%

PhD / Post grad / Masters / Doc 4

44%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 5

56%

Medicine and Dentistry 2

22%

Computer Science 1

11%

Neuroscience 1

11%

Save time finding and organizing research with Mendeley

Sign up for free