New discoveries linking transcription to DNA repair and damage tolerance pathways

Abstract

In Escherichia coli, the transcription elongation factor NusA is associated with all elongating RNA polymerases, where it functions in transcription termination and antitermination. Here, we review our recent results implicating NusA in the recruitment of DNA repair and damage tolerance mechanisms to sites of stalled transcription complexes. © 2011 Landes Bioscience.