Preparation and Characterization of Mucoadhesive Buccal Film for Delivery of Meloxicam

Abstract

Aims: Preparation of mucoadhesive buccal films able to deliver the meloxicam drug to the site of application through oral mucosal tissues. This dosage form is advantageous due to absence the problems of the ordinary dosage forms. Methodology: There are different polymers used in preparation of the films which are hydroxypropylmethyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, pectin and polyvinyl alcohol. Also, the plasticizers used are glycerin, propylene glycol and polyethylene glycol. The film was prepared by solvent casting technique. Firstly, the calibration curve of meloxicam was carried out. Then, the properties of the formulations Research Article British Journal of Pharmaceutical Research, 3(4): 743-766, 2013 744 were examined through some experiments which are determination of drug content, study of efficacy of mucoadhesion, in-vitro drug release studies and differential scanning calorimetry. Results: It was found that the formula containing polyvinyl alcohol 2% (w/w) and propylene glycol 20% from the weight of the polymer has ideal characteristics. Results showed that this formula has optimum drug content, acceptable mucoadhesion and fast drug release with compatibility between drug and excipents.