The off-rate of monomers dissociating from amyloid-β protofibrils

Abstract

Background: Protofibrils of the amyloid-β peptide (Aβ) are neurotoxic oligomers implicated in development and progression of Alzheimer disease. Results: The dissociation of Aβ protofibrils into their monomeric subunits is a slow process, occurring on the time scale of hours. Conclusion: Aβ protofibrils possess a high kinetic stability toward dissociation into monomers. Significance: The longevity of Aβ protofibrils permits sustained toxic effects. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.