Effect of Mangosteen Peel Extract (Garcinia mangostana) on Murine Sepsis Score (MSS) in Sepsis Mice Induced with Shigella dysenteriae

Abstract

This study aimed to determine the effect of mangosteen peel extract (Garcinia mangostana) on Murine Sepsis Score (MSS) in sepsis mice induced by Shigella dysenteriae infection. This study was an experimental study, 30 mice were divided into 5 groups. Each mouse was injected by S. dysenteriae intraperitoneally. On the first day post injection positive control was given Azithromycin 246 mg/kgBW, negative control was given distilled water, the treatment group was given extra mangosteen peels with the following doses: K1= 100 mg/kg body weight, K2= 200 mg/kg body weight, and K3= 400 mg/kg body weight. On the second day post injection according to the bacterial incubation period MSS score for each mouse was calculated. There was a corelation between the administration of mangosteen peel extract with MSS score of mice (p<0.05). There was no significant difference between administration of extracts of 200 mg/kg and 400 mg/kg with Azithromycin.