Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Methamphetamine Use Disorder

Abstract

Objective: Methamphetamine (METH) is a potent central nervous system (CNS) stimulant that rapidly enhances the release of neurotransmitters, including adrenaline, dopamine, and serotonin. It is also one of the most popular illicit drugs of choice worldwide known as “ice”. In this study, we examined the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) levels in patients with methamphetamine use disorder. Materials and Methods: This study included a total of 84 patients with only methamphetamine use and 81 healthy individuals. Participants who had hematological disorders and other chronic diseases were excluded from the study. White blood cell, neutrophil, lymphocyte, and platelet count were compared between groups. NLR and PLR values were calculated and compared between groups. Results: The patient group comprised 81 males and 3 females with the mean age of 26.37 ± 5.99 years. There was no significant difference between patient and control group in terms of age, sex, BMI, smoking status, and alcohol consumption. NLR and PLR ratios were lower in the patient group than controls. NLR and PLR values were positively correlated with daily dosage of METH use (r = 0.227 P = .038, r = 0.228 P = .037, respectively). Conclusion: To the best of our knowledge, our study is the first study examining the relationship between NLR and PLR in patients with METH use disorder. NLR and PLR were found to be lower in patients with METH use disorder. The effects of METH on the immune system should be considered. Prospective, longitudinal studies involving intoxication-detoxification-remission periods are needed.