Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization

Abstract

Solid-state grinding can provide “mechano-distinctive” co-crystals that are not accessible from solutions. Herein, we demonstrate the structure determination of a powdered mechano-distinctive co-crystal of 2-aminopyrimidine and succinic acid in a 2 : 1 molar ratio using microcrystal electron diffraction.