The effect of chloramphenicol and sulphaphenazole on the biotransformation of cyclophosphamide in man.

Abstract

1 The metabolism of cyclophosphamide was investigated before and following treatment with chloramphenicol (five subject) and sulphaphenazole (seven subjects). 2 The biotransformation of cyclophosphamide was retarded after chloramphenicol treatment as indicated by prolongation in the mean serum half‐life from 7.5 h to 11.5 h combined with decreased peak activity and integrated concentrations of metabolites. 3 in the sulphaphenazole treated subjects the rate of biotransformation of cyclophosphamide was significantly inhibited in two, unaltered in three and enhanced in two. The inconsistency of the results is discussed. 1975 The British Pharmacological Society