Journal ArticleOPEN ACCESS

Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo

Molecular Therapy Methods and Clinical Development (2020) 18 652-663
DOI: 10.1016/j.omtm.2020.05.025
5Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Arginase is a unique enzyme that plays a critical role in regulating the outcome of innate and adaptive immune responses. The immunomodulatory capabilities of arginase enzyme could potentially be applied for local inflammation or autoimmune diseases. Here, we report on a DNA-encoded secretable arginase enzyme as a tool for therapeutic immunomodulation.

Author supplied keywords

Cite

CITATION STYLE

APA

Khoshnejad, M., Perales-Puchalt, A., Dia, Y., Xiao, P., Patel, A., Xu, Z., … Weiner, D. B. (2020). Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo. Molecular Therapy Methods and Clinical Development, 18, 652–663. https://doi.org/10.1016/j.omtm.2020.05.025

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free