Calcium Phosphate Scaffold Loaded with Platinum Nanoparticles for Bone Allograft

Abstract

Inflammations are a predicament issue that leads to orthopaedic hard implants failure. Thereby, calcium phosphate platinum scaffolds possess anti-inflammatory properties, as powerful tools for successful bone regeneration. The effects of the platinum nanoparticles (PtNPs) on the scaffold's degradation and proliferation and attachment were evaluated. The scaffolds degradation rates ranged between 50-75 % and 80-95% for Scaffold with and without PtNPs respectively. Moreover, the cells proliferation and attachment on CPs-PtNPs scaffold were superior to CPs scaffold. The results warranted that, the synthesized scaffolds exhibit good biocompatibility and in vitro biodegradation, and also, it could be a used as a substrate for PtNPs delivery.