Considering that short, mainly heterochiral, polypeptides with a high glycine content are expected to have played a prominent role in evolution at the earliest stage of life before nucleic acids were available, we review recent knowledge about polypeptide three-dimensional structure to predict the types of conformations they would have adopted. The possible existence of such structures at this time leads to a consideration of their functional significance, and the consequences for the course of evolution. This article was reviewed by Bill Martin, Eugene Koonin and Nick Grishin. © 2008 Milner-White and Russell; licensee BioMed Central Ltd.
CITATION STYLE
James, E. J., & Russell, M. J. (2008, January 28). Predicting the conformations of peptides and proteins in early evolution. A review article submitted to Biology Direct. Biology Direct. BioMed Central Ltd. https://doi.org/10.1186/1745-6150-3-3
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