Superacid-Induced Reactions of Nefopam

  • Knoecer L
  • DeSchepper D
  • Klumpp D
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Abstract

The analgesic drug nefopam reacts in superacidic media to form a dicationic superelectrophiles by ring opening. The dication species is capable of reacting with arenes in Friedel-Crafts-type conversions. This chemistry is used to prepare novel derivatives of nefopam .

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Knoecer, L., DeSchepper, D., & Klumpp, D. A. (2010). Superacid-Induced Reactions of Nefopam. Organic Chemistry International, 2010, 1–5. https://doi.org/10.1155/2010/496818

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