Endophenazines A∼D, new phenazine antibiotics from the athropod. Associated endosymbiont Streptomyces anulatus. II. Structure elucidation

Abstract

A detailed screening of the secondary metabolite pattern produced by different athropod associated strains of the species Streptomyces anulatus resulted in the isolation and structure elucidation of the endophenazines A ∼ D (2, 4∼6). The structures were assigned by spectroscopic methods and chemical transformations. 4 represents a chromophoric system based on a phenazin-7-one, 5 and 6 are new 5,10-dihydrophenazine derivatives.