clusters of mycobacterium tuberculosis genotypes in odesaregion

Abstract

It has been studied a genotype of 104 strains of Mycobacterium tuberculosis, obtained from sputum of patients with tuberculosis (TB), via detection of six loci VNTR (Variable Number Tandem Repeats), which are characterized by highest polymorphism-MIRU10, MIRU26, MIRU31, MIRU39, MIRU40, ETR-A. According to received data in Odesa region one can see further increasing of spreading of Beijing family strains that are characterized by unfavourable course of TB and high drug-resistance. Polymorphism of certain detected loci of M.tuberculosis decreased relatively to 2006 year that has witnessed an increasing of predominance of certain M. tuberculosis clusters. The highest level of mutations that leads to drug-resistance, were among Beijing family isolates, for instance as 355334, 365334, 375344 and 465334.