Abstract
The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Liang, K., Such, G. K., Johnston, A. P. R., Zhu, Z., Ejima, H., Richardson, J. J., … Caruso, F. (2014). Endocytic pH-triggered degradation of nanoengineered multilayer capsules. Advanced Materials, 26(12), 1901–1905. https://doi.org/10.1002/adma.201305144
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