Role of platelet-rich plasma in soft and hard connective tissue healing: an evidence-based review from basic to clinical application

Abstract

FFF : Moshiri A, Oryan A. Role of platelet rich plasma in soft and hard connective tissue healing: an evidence based review from basic to clinical application. Hard Tissue 2013 Jan 31;2(1):6. Abstract Introduction Platelet-rich plasma is one of the new therapeutic approaches in the field of soft and hard connective tissue healing and repair. Compared with physiologic plasma, platelet-rich plasma has a higher concentration of platelets with or without a higher concentration of leukocytes. The platelet granules contain many critical growth factors necessary for wound healing. After activation in the injured area, the platelets and leukocytes present in platelet-rich plasma release their growth factors, cytokines and proinflammatory mediators. It is believed that by these mechanisms the platelet-rich plasma initiates inflammation, regulates cell migration, proliferation and matrix deposition and reduces the risk of infection in the injured site. Therefore , it appears that platelet-rich plasma may increase the quality of tissue healing and repair. Several in vitro, in vivo and clinical trial studies have tested platelet-rich plasma; however, there are significant controversies between their results. This review, introduces platelet-rich plasma, its methods of preparation and benefits. We have also reviewed those researches that tested platelet-rich plasma from basic to the clinic and showed why these controversies