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Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

Nature Communications (2017) 8(1)
DOI: 10.1038/s41467-017-01009-1
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Abstract

PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.

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Infantino, S., Light, A., O’donnell, K., Bryant, V., Avery, D. T., Elliott, M., … Tarlinton, D. (2017). Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation. Nature Communications, 8(1). https://doi.org/10.1038/s41467-017-01009-1

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