Self-Nanoemulsifying Drug Delivery System of Loratidine for Improved Solubility: Physicochemical Characterization and In vitro Study

Abstract

The primary goal of this study was to investigate whether or not a self-nanoemulsified drug delivery system (SNEDDS) could enhance the oral bioavailability of Loratidine. The solubility experiments were used to choose the excipients used to create SNEDDS, all of which had a high solubilizing capacity for the active ingredient Loratidine.It has a basic pKa of 3.83 and is a BCS class 2b compound with minimal solubility and oral bioavailability. Its solubility and dissolving properties were improved with the development of the Loratadine SNEDDS. The self-emulsifying zone was identified by developing a ternary phase diagram. The best self-nanoemulsified and solubilization-capable formulations included Isopropyl myristate, PEG-400, and Propylene glycol. The phosphate buffer pH 6.8 was used for the drug release investigation of SNEDDS and was contrasted with the commercial tablet. Compared to the tablet currently on the market, the LS4 formulation release was considerably boosted. Findings suggest that SNEDDS might be used to enhance Loratadine's solubility and dissolving properties.