Advanced Functionalized CeO2/Al2 O3 Nanocomposite Sensor for Determination of Opioid Medication Tramadol Hydrochloride in Pharmaceutical Formulations

Abstract

Background: The exceptional characteristics of cerium oxide (CeO2) and aluminum oxide (Al2 O3) nanoscales have inspired significant attention to those nanocomposites as possible electroactive resources for applications of sensing and biosensing. Methods: In this research, an innovative new factionalized CeO2/Al2 O3 nanocomposite membrane sensor was presented to assess tramadol hydrochloride (TRD) in marketable products. Results: Tramadol-phosphomolybdate (TRD-PM) was formed by mixing tramadol hydrochloride and phosphomolybdic acid (PMA) in the attendance of polymeric matrix and o-nitrophenyloctyl ether solvent mediator. With 1.0 × 10−10 –1.0 × 10−2 mol L−1 as a range of linearity and EmV = (57.567 ± 0.2) log [TRD] + 676.29 as a regression equation, the functionalized sensor using TRD-PM-CeO2/Al2 O3 nanocomposite showed great selectivity and sensitivity for the discriminating and measurement of TRD. Using the regression equation EmV = (52.143 ± 0.4) log [TRD] + 431.45, the unmodified coated wire sensor of TRD-PM, on the other hand, showed a Nernstian response between 1.0 × 10−6 and 1.0 × 10−2 mol L−1, Using the methodology’s specified guidelines, the proposed improved potentiometric system was validated against several criteria. Conclusion: The suggested method is suitable for the determination of TRD in its products.