Anti-Infectious Hematopoietic Necrosis Virus(IHNV) Substances Produced by Bacteria from Aquatic Environment

Abstract

Attempts were made to classify the antiviral properties of bacteria which has been isolated from various environmental waters and had the anti-infectious effects on infectious hematopoietic necrosis virus (IHNV). The majority of these bacterial strains were considered to produce the substances that cause direct inactivation of virus or inhibition of viral invasion into CHSE-214 cells. While a few of the isolates were considered to produce the substances that cause inhibition of viral replication. Among the four strains selected, two strains of Pseudomonas produced heat-stable and relatively low molecular weight substances; one strain of Alteromonas produced a high molecular weight, heat-labile substance; and one strain of Pseudomonas produced at least two kinds of substances unstable against heating. © 1993, The Japanese Society of Fish Pathology. All rights reserved.