Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators

Abstract

Peroxisome proliferators (PP) are a large class of structurally dissimilar chemicals. These chemicals have diverse effects in rodents and humans, including regulation of lipid metabolism, growth promotion, and induction of hepatocarcinogenesis. Most, if not all, effects of PP are mediated by three members of the nuclear receptor superfamily called PP-activated receptors (PPAR). In this review, we discuss the evidence that PPARα, the predominant PPAR in the, liver is involved in the growth promoting and hepatocarcinogenic effects of PP. Copyright (C) 2000 Elsevier Science B.V.