A model inquiry-based genetics experiment for introductory biology students: Screening for enhancers & suppressors of Ptpmeg

Abstract

It has been noted that undergraduate project-based laboratories lead to increased interest in scientific research and student understanding of biological concepts. We created a novel, inquiry-based, multiweek genetics research project studying Ptpmeg, for the Introductory Biology Laboratory course at Brandeis University. Ptpmeg is a protein involved in axon formation in Drosophila melanogaster. In order to better understand Ptpmeg's functionality, students sought to find Ptpmeg's enhancers and suppressors by engaging in either a 4- or a 7-week modular research project. By the end of the semester, students were able to learn various laboratory techniques and acquire a deeper understanding of Drosophila genetics in both versions of the course.