P2774Comparison of coronary angioscopic findings after stent implantation among 2 kinds of novel biodegradable polymer-coated and one durable polymer-coated drug-eluting stent

Abstract

Background: Chronic neointimal conditions of novel biodegradable polymercoated drug‐eluting stents are not well investigated. On the other hands, biodegradable polymer is expected to reduce chronic inflammation and produce favorable coverage of neointima on stent. Objectives: We aimed to compare the angioscopic findings among the biodegradable polymer‐coated sirolimus‐eluting stent (BP‐SES) and the biodegradable polymer‐coated everolimus‐eluting stent (BP‐EES) and the durable polymercoated everolimus‐eluting stent (DP‐EES). Methods: We enrolled 78 successive patients who received BP‐SES (n=26), BPEES (n=31) and DP‐EES (n=21), from December 2015 to April 2017, who underwent 8‐month follow‐up coronary angiography and angioscopy. We compared age, the incidence of acute coronary syndrome, diabetes mellitus, hypertension, dyslipidemia, chronic kidney disease and angioscopic parameters including dominant grade of neointimal coverage (NIC) over the stent, maximum yellow plaque grade, existence of red thrombus among three groups of drug eluting stents (DESs). NIC was graded as follows: grade 0: stent struts without endothelialization, grade 1: stent struts with very thin neointimal coverage, grade 2: stent struts without metallic color, grade 3: invisible stent struts with full neointimal coverage. Yellow plaque severity was graded as follows: grade 0: white, grade 1: light yellow, grade 2: yellow and grade 3: intensive yellow. Results: The patient's characteristics including diabetes mellitus, hypertension, dyslipidemia and chronic kidney disease was similar between the three groups. On angioscopic parameters, there was no significant difference but in biodegradable polymer‐coated DESs groups, dominant grade of NIC was relatively higher than durable polymer‐coated DESs and over grade 1 neointimal coverage was found in almost of them at 8‐month after stent implantation. (table) Conclusions: Angioscopic findings revealed that novel biodegradable polymer can produce favorable neointimal coverage. (Table Presented).