Correlations between choroidal abnormalities, lisch nodules, and age in patients with neurofibromatosis type 1

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Abstract

To evaluate correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1 (NF1), we examined ten cases with NF1 using near-infrared reflectance imaging. Patients ranged in age from 4 to 39 years. The angle used for near-infrared reflectance imaging was 55°. We counted the total number of choroidal abnormalities in an area within a 55° angle centered on the fovea and the total number of Lisch nodules on the iris by slit-lamp examination. No positive correlation was found between the number of Lisch nodules and patient age (Spearman's rank correlation coefficient ρ=0.117, P=0.7414). Choroidal abnormalities tended to increase with age (ρ=0.6150), but this difference was not statistically significant (P=0.0650). A positive correlation was found between the number of choroidal abnormalities and Lisch nodules (ρ=0.783, P=0.0267). In conclusion, choroidal abnormalities tend to increase with patient age and are correlated with the number of Lisch nodules. © 2014 Makino et al.

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Makino, S., Tampo, H., Arai, Y., & Obata, H. (2014). Correlations between choroidal abnormalities, lisch nodules, and age in patients with neurofibromatosis type 1. Clinical Ophthalmology, 8, 165–168. https://doi.org/10.2147/OPTH.S56327

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