SP702P-NGAL PREDICTS EARLY, BUT NOT ONE-YEAR GRAFT FUNCTION AFTER DECEASED DONOR KIDNEY TRANSPLANTATION

Abstract

INTRODUCTION AND AIMS: Deceased donor kidney transplantation is associated with a high risk of delayed graft function (DGF). Early detection of graft injury may facilitate adequate clinical management. This study evaluates four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver‐type fatty acid‐binding protein (LFABP), cystatin C, and YKL‐40), their ability to predict DGF, and their association with graft function in the first postoperative days and at 3 and 12 months. METHODS: 222 recipients of a deceased donor kidney transplant were included in a multicenter, randomized, controlled trial. Plasma and urine biomarkers were measured using ELISA or automated assays. DGF was defined as the need for dialysis in the first posttransplant week. Biomarker levels were correlated with mGFR on day 5, and to mGFR and eGFR at 3 and 12 months posttransplant. RESULTS: Plasma NGAL at day 1 predicted DGF (AUC=0.91). Early biomarker levels and eGFR at 3 or 12 months correlated not at all or only weakly. CONCLUSIONS: High plasma NGAL at day 1 predicts DGF, but early biomarker levels did not correlate with one year graft function.